Product Description of Triethylamine CAS#121-44-8
Triethylamine (chemical formula C₆H₁₅N), also called N,N-diethylethylamine, is the simplest representative of homotrisubstituted tertiary amines. It demonstrates the typical reactivity of this class, including the formation of salts and oxidation reactions, while showing no activity in the Hinsberg reaction.
In physical appearance, triethylamine is a colorless to light yellow transparent liquid with a strong odor reminiscent of ammonia and a slight tendency to fume in air. Its boiling point is 89.5°C, its density is 0.70 g/cm³ (relative to water), and its vapor density is 3.48 (relative to air). It is only marginally soluble in water, but mixes readily with ethanol and ether, forming an alkaline aqueous solution.
Triethylamine is a flammable liquid whose vapors can generate explosive mixtures with air at concentrations ranging from 1.2% to 8.0%. Additionally, it is toxic and has a high irritancy profile, so it must be handled with appropriate protective measures and strict safety controls.
Triethylamine Chemical Properties
| Melting point | -115 °C |
| Boiling point | 90 °C |
| density | 0.728 |
| vapor density | 3.5 (vs air) |
| vapor pressure | 51.75 mm Hg ( 20 °C) |
| refractive index | n20/D 1.401(lit.) |
| FEMA | 4246 | TRIETHYLAMINE |
| Fp | 20 °F |
| storage temp. | Store below +30°C. |
| solubility | water: soluble112g/L at 20°C |
| pka | 10.75(at 25℃) |
| form | Liquid |
| Specific Gravity | 0.725 (20/4℃) |
| color | Clear |
| PH | 12.7 (100g/l, H2O, 15℃)(IUCLID) |
| Relative polarity | 1.8 |
| Odor | Strong ammonia-like odor |
| Odor Type | fishy |
| Odor Threshold | 0.0054ppm |
| explosive limit | 1.2-9.3%(V) |
| Water Solubility | 133 g/L (20 ºC) |
| Merck | 149666 |
| JECFA Number | 1611 |
| BRN | 1843166 |
| Henry's Law Constant | 1.79 at 25 °C (Christie and Crisp, 1967) |
| Exposure limits | NIOSH REL: IDLH 200 ppm; OSHA PEL: TWA 25 ppm (100 mg/m3); ACGIH TLV: TWA 1 ppm, STEL 3 ppm (adopted). |
| Dielectric constant | 5.0（Ambient） |
| Stability: | Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons. |
| InChIKey | ZMANZCXQSJIPKH-UHFFFAOYSA-N |
| LogP | 1.65 |
| CAS DataBase Reference | 121-44-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Triethylamine(121-44-8) |
| EPA Substance Registry System | Triethylamine (121-44-8) |
Safety Information
| Hazard Codes | F,C |
| Risk Statements | 11-20/21/22-35 |
| Safety Statements | 3-16-26-29-36/37/39-45-61 |
| RIDADR | UN 1296 3/PG 2 |
| WGK Germany | 1 |
| RTECS | YE0175000 |
| F | 34 |
| Autoignition Temperature | 593 °F |
| Hazard Note | Highly Flammable/Corrosive |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29211910 |
| Hazardous Substances Data | 121-44-8(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 0.46 g/kg (Smyth) |
| IDLA | 200 ppm |
Product Application of Triethylamine CAS#121-44-8
Triethylamine is extensively utilized as both a solvent and a raw material in organic synthesis. It serves as a key intermediate in the production of phosgene-based polycarbonate catalysts, tetrafluoroethylene inhibitors, rubber vulcanization accelerators, specialized paint stripper solvents, enamel anti-hardening agents, surfactants, preservatives, bactericides, ion-exchange resins, dyes, fragrances, pharmaceuticals, high-energy fuels, and liquid rocket propellants.
In the pharmaceutical sector, triethylamine is employed in the manufacture of a wide range of products, including ampicillin sodium, amoxicillin, Pioneer IV, cefazolin sodium, cefradine, piperacillin, ketoconazole, vitamin B6, fluoxic acid, praziquantel, thiotepa, penicillamine, berberine hydrochloride, isoprenaline, alprazolam, o-chlorophenylacetic acid, pipemidic acid, and various other medicinal compounds.
Additional applications include the preparation of quaternary ammonium compounds, catalyst synthesis, and the production of rubber vulcanization accelerators, penetrants, and waterproofing agents.
In analytical chemistry, triethylamine is used as a mobile phase modifier in reversed-phase high-performance liquid chromatography (RP-HPLC) to improve the separation of acidic, basic, and neutral compounds. It also helps reduce peak tailing during chromatographic analysis, particularly for amino acids and amino acid amides.
Furthermore, triethylamine is widely applied in the manufacture of pharmaceuticals, pesticides, inhibitors, high-energy fuels, and rubber vulcanizing agents.
