D-Camphorsulfonic Acid CAS#3144-16-9
D-Camphorsulfonic Acid represents a class of chiral organic sulfonic acid defined by its one-of-a-kind molecular architecture and distinct set of chemical traits. Functioning as a high-priority intermediate in organic synthesis, it has secured widespread adoption across pharmaceutical manufacturing, asymmetric catalysis, and a broad spectrum of other high-end chemical application scenarios.
Thanks to its inherent chiral attributes, this compound can act as a chiral inducing agent in asymmetric reaction systems, streamlining the production of target compounds with predefined stereochemical configurations. Beyond that, it demonstrates notable acidic reactivity, and is capable of undergoing neutralization reactions with alkaline substrates to generate matching salt derivatives, which greatly extends its application adaptability in various chemical processing workflows.
(1S)-(+)-Camphor-10-sulphonic acid Chemical Properties
| Product Name: | (1S)-(+)-Camphor-10-sulphonic acid |
| Synonyms: | D-CAMPHORSULFONIC ACID;D(-)-CAMPHORSULPHONIC ACID;D-CAMPHORSULPHONIC ACID;CSA;D-REYCHLER'S ACID;D-OXO-10-BORNANESULFONIC ACID;(+)-BETA-CAMPHORSULFONIC ACID;(+)-CAMPHOR-10-SULFONIC ACID (BETA) |
| CAS: | 3144-16-9 |
| MF: | C10H16O4S |
| MW: | 232.3 |
| EINECS: | 221-554-1 |
| Product Categories: | chiral;Pharmaceutical Intermediates;FINE Chemical & INTERMEDIATES;Chiral Compounds;Bicyclic Monoterpenes;Biochemistry;for Resolution of Bases;Optical Resolution;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Terpenes;Peptide;Sulfur & Selenium Compounds;3144-16-9;3597-91-9;11 |
| Mol File: | 3144-16-9.mol |
| Melting point | 196-200 °C (dec.)(lit.) |
| alpha | 22 º (589nm, c=20, H2O 25 ºC) |
| Boiling point | 344.46°C (rough estimate) |
| density | 1.2981 (rough estimate) |
| refractive index | 21.5 ° (C=5, H2O) |
| storage temp. | Store below +30°C. |
| solubility | Exhibit moderate solubility in HCCl. |
| form | Crystalline Powder |
| pka | 1.17±0.50(Predicted) |
| color | White to off-white |
| PH | 0.3 (200g/l, H2O) |
| optical activity | [α]20/D +21.5±1°, c = 10% in H2O |
| biological source | human |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| Merck | 141734 |
| BRN | 2809675 |
| Stability: | Stable. Protect from moisture. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | MIOPJNTWMNEORI-GMSGAONNSA-N |
| CAS DataBase Reference | 3144-16-9(CAS DataBase Reference) |
| EPA Substance Registry System | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)- (3144-16-9) |
Product Usage
(1S)-(+)-Camphor-10-sulfonic Acid sees extensive industrial and laboratory application as both a high-performance stabilizing agent and a highly efficient chiral resolution reagent. Benefiting from its exceptional chiral recognition performance, it is routinely deployed in enantiomer separation operations and a wide range of asymmetric synthesis workflows.
It also functions as a functional dopant during the template-free potentiostatic electropolymerization process for producing chiral polyaniline (PANI) nanofibers, where either (1S)-(+)-camphor-10-sulfonic acid (D-CSA) or (1R)-(-)-camphor-10-sulfonic acid (L-CSA) is incorporated to introduce targeted chirality into the final product. Furthermore, it acts as a critical foundational raw material for manufacturing quaternary ammonium compounds (QUATs) that are derived from the (1S)-(+)-camphor-10-sulfonic acid parent structure.
