Pagoclone

GABA Receptor Modulation – Pagolone acts as a specific modulator of GABA (Gamma-aminobutyric acid) receptors, contributing to the regulation of GABAergic signaling.

Potential Benefit for Stuttering – Studies suggest that Pagolone may help reduce stuttering through its influence on GABA(A) receptor activity.

Novel Cyclopyrrolone Structure – As a new cyclopyrrolone derivative, Pagolone offers distinctive pharmacological characteristics relative to conventional GABA-targeting agents.

Partial GABA(A) Receptor Agonist – Functioning as a partial agonist at GABA(A) receptors, Pagolone provides targeted regulation of inhibitory neurotransmission.

Product Description
Chemical Properties

Product Description of Pagoclone CAS#133737-32-3

Pagoclone is a selective GABA receptor modulator that has shown promise in reducing stuttering. As a novel cyclopyrrolone compound, it acts as a partial agonist at the GABA(A) receptor site, giving it a distinct pharmacological profile compared with other agents in its class.

Pagoclone

PAGOCLONE Chemical Properties

Boiling point 582.1±50.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
pka1.62±0.30(Predicted)
InChIInChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3
InChIKeyHIUPRQPBWVEQJJ-UHFFFAOYSA-N
SMILESC1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2
Pagoclone

Product Application of Pagoclone CAS#133737-32-3 

Pagoclone is a selective GABA (gamma-aminobutyric acid) receptor modulator that holds promise for reducing stuttering. It belongs to the cyclopyrrolone class of compounds and acts as a partial agonist at the GABA(A) receptor site.

Pagoclone