Polyethylene-Polypropylene Glycol CAS#9003-11-6
Pluronic® F-127 is a nonionic surfactant extensively utilized to solubilize hydrophobic compounds, encompassing cell-permeable AM esters (for instance, Fluo-4 and Fluo-8 calcium indicators) and potentiometric probes (such as Di-4-ANEPS and Di-8-ANEPS), while concurrently aiding in their efficient cellular internalization.
We offer Pluronic® F-127 in the form of a ready-to-use 10% aqueous solution, providing operational convenience and reducing preparation time in laboratory workflows.
In a typical application, the 10% Pluronic® F-127 solution in water is employed to facilitate the loading of AM ester ion indicators and other fluorescent dyes into cells. The precise loading parameters may require adjustment depending on the cell type and the specific compounds involved.
Polyethylene-polypropylene glycol Chemical Properties
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| bulk density | 1050kg/m3 |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n20/D 1.466 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| PH Range | 5.0 - 7.5 |
| biological source | synthetic |
| Water Solubility | Miscible with water. |
| λmax | λ: 260 nm Amax: ≤0.3 |
| λ: 280 nm Amax: ≤0..2 | |
| Merck | 137644 |
| Hydrophilic-Lipophilic Balance (HLB) | 18 - 23 |
| Cosmetics Ingredients Functions | SURFACTANT - CLEANSING |
| SURFACTANT - HYDROTROPE | |
| CLEANSING | |
| SOLVENT | |
| HUMECTANT | |
| EMULSION STABILISING | |
| BINDING | |
| SURFACTANT - EMULSIFYING | |
| VISCOSITY CONTROLLING | |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2 |
| InChIKey | RVGRUAULSDPKGF-UHFFFAOYSA-N |
| SMILES | O2C(C2)C.O1CC1 |
| LogP | -1.293 (est) |
| EPA Substance Registry System | Poloxalene (9003-11-6) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 21-23/24/25-25-36/37/38 |
| Safety Statements | 23-24/25-45-36/37/39-26 |
| WGK Germany | 3 |
| RTECS | TP6164333 |
| TSCA | TSCA listed |
| HS Code | 39059100 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 9003-11-6(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: 35gm/kg |
Product Application of Polyethylene-Polypropylene Glycol CAS#9003-11-6
All grades of polyethylene-polypropylene glycol share a similar chemical composition, differing mainly in the relative proportions of ethylene oxide and propylene oxide introduced during production. As a result, their physical and surfactant properties vary over a wide range, and multiple commercial grades are available.
In pharmaceutical applications, it is widely used as an emulsifier in intravenous fat emulsions, as well as a solubilizing and stabilizing agent to maintain the clarity of elixirs and syrups.
Additionally, it can function as a wetting agent, and is commonly applied in ointments, suppository bases, and gels, as well as serving as a binder and coating material in tablet formulations.
